Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

@article{Gale2015SimpsonsPA,
  title={Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.},
  author={Rosemary E Gale and Katarina Lamb and Christopher Allen and Dima El-Sharkawi and Cassandra Stowe and Sarah. F. Jenkinson and Steven Tinsley and Glenda Dickson and Alan K. Burnett and Robert K. Hills and David Christopher Linch},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2015},
  volume={33 18},
  pages={2072-83}
}
PURPOSE To evaluate the impact of DNMT3A mutations on outcome in younger patients with cytogenetic intermediate-risk acute myeloid leukemia. PATIENTS AND METHODS Diagnostic samples from 914 patients (97% < 60 years old) were screened for mutations in DNMT3A exons 13 to 23. Clinical outcome was evaluated according to presence or absence of a mutation and stratified according to type of mutation (R882, non-R882 missense, or truncation). RESULTS DNMT3A mutations (DNMT3A(MUT)) were identified… CONTINUE READING