Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking


To the editor: A key problem in managing prion diseases is the lack of a rapid, practical assay for prions (infectivity) at low-level infectious, or sub-infectious, amounts. Prion diseases involve the accumulation of a pathological, typically protease-resistant form of prion protein, termed PrPSc, which appears to propagate itself in infected hosts by… (More)
DOI: 10.1038/nmeth0308-211

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