Simplified strategy for detection of recombinant human immunodeficiency virus type 1 group M isolates by gag/env heteroduplex mobility assay. Study Group on Heterogeneity of HIV Epidemics in African Cities.

@article{Heyndrickx2000SimplifiedSF,
  title={Simplified strategy for detection of recombinant human immunodeficiency virus type 1 group M isolates by gag/env heteroduplex mobility assay. Study Group on Heterogeneity of HIV Epidemics in African Cities.},
  author={L. Heyndrickx and Wouter Janssens and L{\'e}opold Zekeng and Rosemary Mubanga Musonda and S{\'e}verin Yehou{\'e}nou Anagonou and Gert Van der Auwera and Sandra Coppens and Katleen Vereecken and Karel De Witte and R Van Rampelbergh and Maina Kahindo and Linda Morison and Francine E. McCutchan and Jean Kirkland Carr and Jan Albert and Max Essex and Jaap Goudsmit and Birgitta {\AA}sj{\"o} and Mika Salminen and Anne M Buv{\'e} and Guido van der Groen},
  journal={Journal of virology},
  year={2000},
  volume={74 1},
  pages={363-70}
}
We developed a heteroduplex mobility assay in the gag gene (gag HMA) for the identification of group M subtypes A to H. The assay covers the region coding for amino acid 132 of p24 to amino acid 20 of p7 (according to human immunodeficiency virus type 1 [HIV-1] ELI, 460 bp). The gag HMA was compared with sequencing and phylogenetic analysis of an evaluation panel of 79 HIV-1 group M isolates isolated from infected individuals from different geographic regions. Application of gag HMA in… CONTINUE READING
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