Simplified models of biological networks.

  title={Simplified models of biological networks.},
  author={Kim Sneppen and Sandeep Krishna and Szabolcs Semsey},
  journal={Annual review of biophysics},
The function of living cells is controlled by complex regulatory networks that are built of a wide diversity of interacting molecular components. The sheer size and intricacy of molecular networks of even the simplest organisms are obstacles toward understanding network functionality. This review discusses the achievements and promise of a bottom-up approach that uses well-characterized subnetworks as model systems for understanding larger networks. It highlights the interplay between the… CONTINUE READING