Simplified micro-scale procedure for preparing samples for theophylline determination by liquid chromatography.


We describe an improved procedure for the preparation of plasma or serum for determination of theophylline by reverse phase high-performance liquid chromatography. Quantitative results are available in less than 30 min from receipt of sample. The chromatogram is complete in 8 to 16 min, which includes the use of an internal standard. Sample preparation… (More)


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