Simplified high performance liquid chromatographic method for the determination of clonazepam and other benzodiazepines in serum.

@article{Haver1986SimplifiedHP,
  title={Simplified high performance liquid chromatographic method for the determination of clonazepam and other benzodiazepines in serum.},
  author={V. Haver and W. Porter and L. D. Dorie and J. Lea},
  journal={Therapeutic drug monitoring},
  year={1986},
  volume={8 3},
  pages={
          352-7
        }
}
  • V. Haver, W. Porter, +1 author J. Lea
  • Published 1986
  • Chemistry, Medicine
  • Therapeutic drug monitoring
  • A convenient and sensitive high performance liquid chromatographic method was developed for determination of clonazepam in serum using a C-18 reverse-phase column, and mobile phase consisting of a 50:35:15 mixture by volume of pH 6.0 phosphate buffer:methanol:acetonitrile. Quantitation was performed at 313 nm with flunitrazepam as the internal standard. Using 1 ml of serum for extraction, the assay is linear for clonazepam concentrations between 10 and 250 ng/ml. The relative recovery averaged… CONTINUE READING
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