Simplified flexibility analysis of proteins

  title={Simplified flexibility analysis of proteins},
  author={Yves‐Henri Sanejouand},
  journal={arXiv: Biomolecules},
  • Y. Sanejouand
  • Published 19 December 2013
  • Physics
  • arXiv: Biomolecules
A simple way to get insights about the possible functional motions of a protein is to perform a normal mode analysis (NMA). Indeed, it has been shown that low-frequency modes thus obtained are often closely related to domain motions involved in protein function. Moreover, because protein low-frequency modes are known to be robust, NMA can be performed using coarse-grained models. As a consequence, it can be done for large ensembles of conformations as well as for large systems, like the… 


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