Simplified exactly solvable model for β-amyloid aggregation.

Abstract

We propose an exactly solvable simplified statistical mechanical model for the thermodynamics of β-amyloid aggregation, generalizing a well-studied model for protein folding. The monomer concentration is explicitly taken into account as well as a nontrivial dependence on the microscopic degrees of freedom of the single peptide chain, both in the α-helix folded isolated state and in the fibrillar one. The phase diagram of the model is studied and compared to the outcome of fibril formation experiments which is qualitatively reproduced.

Cite this paper

@article{Zamparo2010SimplifiedES, title={Simplified exactly solvable model for β-amyloid aggregation.}, author={Marco Zamparo and Antonio Trovato and Amos Maritan}, journal={Physical review letters}, year={2010}, volume={105 10}, pages={108102} }