• Chemistry, Medicine
  • Published in Clinical chemistry 1972

Simplified colorimetric determination of thiocyanate in biological fluids, and its application to investigation of the toxic amblyopias.

@article{Pettigrew1972SimplifiedCD,
  title={Simplified colorimetric determination of thiocyanate in biological fluids, and its application to investigation of the toxic amblyopias.},
  author={A. R. Pettigrew and Gordon S. Fell},
  journal={Clinical chemistry},
  year={1972},
  volume={18 9},
  pages={
          996-1000
        }
}
A colorimetric procedure for determination of small amounts of cyanide and thiocyanate, involving the synthesis of a pyridine dyestuff by the reaction of pyridine and an aromatic amine, has been simplified for the estimation of thiocyanate alone in biological fluids. Replacement of benzidine with p -phenylenediamine in the colorimetric reaction has both improved the precision of the analytical procedure and avoided a carcinogenic hazard. This method has been used to follow the decrease in… CONTINUE READING

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