Simplified amino acid alphabets based on deviation of conditional probability from random background.

Abstract

The primitive data for deducing the Miyazawa-Jernigan contact energy or blocks substitution matrix (BLOSUM) consists of pair frequency counts. Each amino acid corresponds to a conditional probability distribution. Based on the deviation of such a conditional probability from random background, a scheme for the reduction of the amino acid alphabet is… (More)
DOI: 10.1103/PhysRevE.66.021906

Topics

4 Figures and Tables

Slides referencing similar topics