Simplified Quantification of Myocardial Flow Reserve with flurpiridaz F 18: Validation with Microspheres in a Pig Model

  title={Simplified Quantification of Myocardial Flow Reserve with flurpiridaz F 18: Validation with Microspheres in a Pig Model},
  author={H. Sherif and S. Nekolla and A. Saraste and S. Reder and M. Yu and S. Robinson and M. Schwaiger},
  journal={The Journal of Nuclear Medicine},
  pages={617 - 624}
  • H. Sherif, S. Nekolla, +4 authors M. Schwaiger
  • Published 2011
  • Chemistry, Medicine
  • The Journal of Nuclear Medicine
  • The novel PET flow tracer flurpiridaz F 18 shows high myocardial extraction and slow washout. flurpiridaz F 18 PET data analysis with tracer kinetic modeling provides accurate absolute myocardial blood flow (MBF) measurements but requires in-scanner injection and complex processing. We evaluated the hypothesis that myocardial retention and standardized uptake values (SUVs) based on late uptake provide accurate estimates of myocardial flow reserve (MFR) and, thus, might allow simplified… CONTINUE READING
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