Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.

@article{Marwood1999SimplificationOA,
  title={Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.},
  author={R. D. Marwood and A. Riley and V. Corr{\^e}a and C. Taylor and B. Potter},
  journal={Bioorganic & medicinal chemistry letters},
  year={1999},
  volume={9 3},
  pages={
          453-8
        }
}
  • R. D. Marwood, A. Riley, +2 authors B. Potter
  • Published 1999
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • The synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-alpha-D-glucopyranosid e 3,4,3'-trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a potential minimal structure for potent glucopyranoside-based agonists of Ins(1,4,5)P3 receptors. 
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