Simplexins A-I, eunicellin-based diterpenoids from the soft coral Klyxum simplex.

@article{Wu2009SimplexinsAE,
  title={Simplexins A-I, eunicellin-based diterpenoids from the soft coral Klyxum simplex.},
  author={Sonya L. Wu and Jui-hsin Su and Zhuqing Wen and Chi-Hsin Hsu and Bo Wei Chen and Chang-feng Dai and Yau Hwang Kuo and Jennline Sheu},
  journal={Journal of natural products},
  year={2009},
  volume={72 6},
  pages={
          994-1000
        }
}
Nine new eunicellin-based diterpenoids, simplexins A-I (1-9), were isolated from a Dongsha Atoll soft coral, Klyxum simplex. The structures of these compounds were established by detailed spectroscopic analysis (IR, MS, 1D and 2D NMR) and by comparison with the physical and spectral data of related known compounds. The absolute configuration of 1 was determined by a modified Mosher's method. Compounds 1, 4, and 5 were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 5… CONTINUE READING
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