Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.

@article{Wheeler2009SimpleVM,
  title={Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.},
  author={Grant N Wheeler and Andr{\'e} W. Br{\"a}ndli},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 6},
  pages={1287-308}
}
Chemical genetics uses small molecules to modulate protein function and, in principle, has the potential to perturb any biochemical event in a complex cellular context. The application of chemical genetics to dissect biological processes has become an attractive alternative to mutagenesis screens due to its technical simplicity, inexpensive reagents, and low-startup costs. In vertebrates, only fish and amphibians are amenable to chemical genetic screens. Xenopus frogs share a long evolutionary… CONTINUE READING

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