Simple synthesis of modafinil derivatives and their anti-inflammatory activity.

@article{Jung2012SimpleSO,
  title={Simple synthesis of modafinil derivatives and their anti-inflammatory activity.},
  author={Jae-Chul Jung and Yeonju Lee and Jee-Young Son and Eunyoung Lim and Mankil Jung and Seikwan Oh},
  journal={Molecules},
  year={2012},
  volume={17 9},
  pages={10446-58}
}
Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling reactions. We determined the anti-inflammatory effects of modafinil derivatives in cultured BV2 cells by measuring the inhibition of nitrite production and expression of iNOS and COX-2 after LPS stimulation. It was found that for sulfide analogues introduction of aliphatic groups on the amide part (compounds 11a–d) resulted in lower anti… CONTINUE READING

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