Simple sequence repeats in prokaryotic genomes.

  title={Simple sequence repeats in prokaryotic genomes.},
  author={Jan Mr{\'a}zek and Xiangxue Guo and Apurva B Shah},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 20},
Simple sequence repeats (SSRs) in DNA sequences are composed of tandem iterations of short oligonucleotides and may have functional and/or structural properties that distinguish them from general DNA sequences. They are variable in length because of slip-strand mutations and may also affect local structure of the DNA molecule or the encoded proteins. Long SSRs (LSSRs) are common in eukaryotes but rare in most prokaryotes. In pathogens, SSRs can enhance antigenic variance of the pathogen… CONTINUE READING


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