Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.

@article{Mattocks1989SimplePF,
  title={Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.},
  author={A. R. Mattocks and Rebekah Jukes and J William L Brown},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1989},
  volume={27 5},
  pages={561-7}
}
New procedures are described for converting unsaturated pyrrolizidine alkaloids to chemically reactive pyrrolic esters (dehydro-alkaloids), which are probable primary toxic metabolites formed from these alkaloids in vivo. Preparations of dehydro-necines, including dehydroretronecine (DHR) are also described. Dehydrocrotanecine, and four new dehydro-alkaloids, are described for the first time. The methods give superior yields to earlier procedures, do not require a high degree of chemical… CONTINUE READING