Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures.

  title={Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures.},
  author={Umut A. Gurkan and Yantao Fan and Feng Xu and Burcu Erkmen and Emel Sokullu Urkac and Gunes Parlakgul and Jacob G. Bernstein and Wangli Xing and Edward S. Boyden and Utkan Demirci},
  journal={Advanced materials},
  volume={25 8},
Natural organs are spatially heterogeneous, both in material composition and in the cell types within. Engineered tissues, in contrast, remain challenging to create, especially if the goal is to spatially position multiple cell types in a heterogeneous pattern in three dimensions (3D). Here, we describe a simple, inexpensive, yet extremely precise method to create tissue architectures in a digitally specifi able fashion, with morphological and compositional tuning. Specifi cally, we pattern… CONTINUE READING
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DOI: 10.1002/adma

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