Simple physical models connect theory and experiment in protein folding kinetics.

@article{Alm2002SimplePM,
  title={Simple physical models connect theory and experiment in protein folding kinetics.},
  author={Eric John Alm and Alexandre V. Morozov and Tanja Kortemme and David Baker},
  journal={Journal of molecular biology},
  year={2002},
  volume={322 2},
  pages={
          463-76
        }
}
Our understanding of the principles underlying the protein-folding problem can be tested by developing and characterizing simple models that make predictions which can be compared to experimental data. Here we extend our earlier model of folding free energy landscapes, in which each residue is considered to be either folded as in the native state or completely disordered, by investigating the role of additional factors representing hydrogen bonding and backbone torsion strain, and by using a… CONTINUE READING

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