Simple methodology for the therapeutic drug monitoring of the tyrosine kinase inhibitors dasatinib and imatinib.

Abstract

A simple HPLC method has been developed to measure imatinib and N-desmethylimatinib (norimatinib) in plasma or serum at concentrations attained during therapy. Adaptation of this method to LC-MS/MS also allows dasatinib assay. A small sample volume (100 μL HPLC-UV, 50 μL LC-MS/MS) is required and analysis time is <5 min in each case. Detection was by UV… (More)
DOI: 10.1002/bmc.2796

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@article{Birch2013SimpleMF, title={Simple methodology for the therapeutic drug monitoring of the tyrosine kinase inhibitors dasatinib and imatinib.}, author={Michael Kevin Birch and Patricio E. Morgan and Simon Handley and Alexander J Ho and Robin M Ireland and Robert James Flanagan}, journal={Biomedical chromatography : BMC}, year={2013}, volume={27 3}, pages={335-42} }