Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.

@article{Guo2010SimpleIV,
  title={Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.},
  author={Jian-Ping Guo and Sheng Yu and Patrick L. Mcgeer},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={19 4},
  pages={1359-70}
}
Compounds that will inhibit buildup of amyloid-beta(Abeta) deposits in Alzheimer's disease (AD) brain are potential therapeutic agents. Here we report the development of two simple in vitro screening assays to identify such agents. We use these assays to evaluate the relative potency of some possible candidates. One assay is based on binding of fluorescence-tagged Abeta{1-42} to synthetic Abeta{1-42} plated in wells of fluorescent black-wall microplates. Fluorescence-tagged Abeta{1-42… CONTINUE READING

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