Simple in vitro assay for determining the sensitivity of Plasmodium vivax isolates from fresh human blood to antimalarials in areas where P. vivax is endemic.

@article{Russell2003SimpleIV,
  title={Simple in vitro assay for determining the sensitivity of Plasmodium vivax isolates from fresh human blood to antimalarials in areas where P. vivax is endemic.},
  author={Bruce M. Russell and Rachanee Udomsangpetch and Karl H. Rieckmann and Barbara M. Kotecka and Russell E. Coleman and Jetsumon Sattabongkot},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 1},
  pages={
          170-3
        }
}
The aim of this study was to develop a simple, field-practical, and effective in vitro method for determining the sensitivity of fresh erythrocytic Plasmodium vivax isolates to a range of antimalarials. The method used is a modification of the standard World Health Organization (WHO) microtest for determination of P. falciparum drug sensitivity. The WHO method was modified by removing leukocytes and using a growth medium supplemented with AB(+) serum. We successfully carried out 34 in vitro… CONTINUE READING

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