Simple gas-liquid chromatographic method for the measurement of mexiletine and lignocaine in blood-plasma or serum.

Abstract

A simple method has been developed for the measurement of mexiletine and lignocaine in blood-plasma or serum at the concentrations attained during therapy. A relatively small (200 microliter) sample volume is made basic and extracted with 50 microliter of chloroform containing internal standards, and the extract is analysed directly by gas-liquid… (More)

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