Simple epithelium keratins are required for maintenance of hepatocyte integrity.

@article{Loranger1997SimpleEK,
  title={Simple epithelium keratins are required for maintenance of hepatocyte integrity.},
  author={Anne Loranger and Sandrine Duclos and Alain Adrien Grenier and James Paschall Price and Marcia Wilson-Heiner and H{\'e}l{\`e}ne Baribault and Normand Marceau},
  journal={The American journal of pathology},
  year={1997},
  volume={151 6},
  pages={
          1673-83
        }
}
Keratin 8 (K8)-deficient adult mice develop a severe disease of the gastrointestinal tract characterized mainly by colorectal hyperplasia and inflammation. Given that hepatocytes contain K8/K18 heteropolymers only, this animal model was used to assess the contribution of these simple epithelium keratins to hepatocyte structural and functional integrity. Homozygous mutant (HMZ), heterozygous, and wild-type (WT) mice were examined for hepatocyte structural and metabolic features and their… CONTINUE READING

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