Simple deuterium introduction at α-position of carbonyl in diazirinyl derivatives for photoaffinity labeling

@article{Murai2010SimpleDI,
  title={Simple deuterium introduction at α-position of carbonyl in diazirinyl derivatives for photoaffinity labeling},
  author={Yuta Murai and M. Takahashi and Yasuyuki Muto and Y. Hatanaka and M. Hashimoto},
  journal={Heterocycles},
  year={2010},
  volume={82},
  pages={909-915}
}
  • Yuta Murai, M. Takahashi, +2 authors M. Hashimoto
  • Published 2010
  • Chemistry
  • Heterocycles
    • Post-functional deuterium incorporation into diazirinyl acetophenone derivatives is reported. Treatment of the compounds with sodium hydroxide in CH 3 OD at rt for 10 min achieved deuterium incorporation at α-position of the carbonyl group without decomposition of diazirinyl ring. Further deuterium can introduce by reduction of benzyl carbonyl with triethylsilane-d-TFA. Straightforward deuterium introduction into diazirinyl derivatives may contribute to the functional analysis of low molecular… CONTINUE READING
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