Simple chemicals can induce maturation and apoptosis of dendritic cells.

@article{Manome1999SimpleCC,
  title={Simple chemicals can induce maturation and apoptosis of dendritic cells.},
  author={Hideaki Manome and Setsuya Aiba and Hachiro Tagami},
  journal={Immunology},
  year={1999},
  volume={98 4},
  pages={481-90}
}
As is well known in the case of Langerhans cells, dendritic cells (DCs) play a crucial role in the initiation of immunity to simple chemicals such as noted in the contact hypersensitivity. Because DCs are scattered in non-lymphoid organs as immature cells, they must be activated to initiate primary antigen-specific immune reactions. Therefore, we hypothesized that some simple chemicals must affect the function of DCs. In this paper, we first demonstrated that human monocyte-derived DCs… CONTINUE READING

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