Simple and sensitive liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera.

@article{Shen2009SimpleAS,
  title={Simple and sensitive liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera.},
  author={P. Shen and S. P. Wong and J. Li and E. Yong},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 1-2},
  pages={
          71-8
        }
}
  • P. Shen, S. P. Wong, +1 author E. Yong
  • Published 2009
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
A rapid and sensitive method to separate and quantify icariin, icariside I, icariside II, icaritin and desmethylicaritin in rat sera was developed using liquid chromatography-tandem mass spectrometry. Serum samples were extracted with ethyl acetate without further derivatization. Using coumestrol as an internal standard, calibration curves with good linearity (r(2)>0.99) within the concentration range of 0.78-12.5 nM for icariin, icaritin and desmethylicaritin, and 0.78-100 nM for icariside I… Expand
Ultra-high performance liquid chromatography-tandem mass spectrometry for the quantification of icaritin in mouse bone.
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  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
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Dynamic Biodistribution of Icaritin and Its Phase-II Metabolite in Rat Tissues by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.
  • Shuang-Qing Zhang
  • Chemistry, Medicine
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • 2016
Pharmacokinetics and metabolism of icaritin in rats by UPLC‐MS/MS
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  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
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LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma.
Simultaneous determination of metoprolol succinate and amlodipine besylate in human plasma by liquid chromatography-tandem mass spectrometry method and its application in bioequivalence study.
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HPLC analysis and pharmacokinetics of icariin in rats.
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