Simple and rapid liquid chromatography method for determination of efavirenz in plasma.

@article{Ramachandran2006SimpleAR,
  title={Simple and rapid liquid chromatography method for determination of efavirenz in plasma.},
  author={G. Ramachandran and Agibothu Kupparam Hemanth Kumar and S. S. Swaminathan and Parthiban Venkatesan and Vasanthapuram Kumaraswami and David J Greenblatt},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2006},
  volume={835 1-2},
  pages={131-5}
}
A simple and rapid high performance liquid chromatographic method for determination of efavirenz in human plasma was developed. The method involved extraction of sample with ethyl acetate and analysis using a reversed-phase C(18) column (150 mm) with UV detection. The assay was linear from 0.0625 to 10.0 microg/ml. The method was specific for efavirenz estimation and the drug was stable in plasma up to one month at -20 degrees C. The average recovery of efavirenz from plasma was 101%. Due to… CONTINUE READING

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