Simple and rapid high-pressure liquid chromatographic simultaneous determination of aspirin, salicylic acid, and salicyluric acid in plasma.

@article{Peng1978SimpleAR,
  title={Simple and rapid high-pressure liquid chromatographic simultaneous determination of aspirin, salicylic acid, and salicyluric acid in plasma.},
  author={Geoffrey W. Peng and Mohamed A. F. Gadalla and Vernon Smith and A T Peng and Win L. Chiou},
  journal={Journal of pharmaceutical sciences},
  year={1978},
  volume={67 5},
  pages={710-2}
}
A rapid and sensitive high-pressure liquid chromatographic assay was developed for aspirin, salicylic acid, and salicyluric acid in plasma. The procedure involves the solvent extraction of these compounds from plasma and separation using a reversed-phase column eluted by acidified aqueous acetonitrile. Small quantitites of aspirin can be assayed directly in the presence of a large quantity of salicylic acid. The assay is also free from blank interference. 

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