Simple and efficient access to N-tosyl beta-amino ketones and their conversion into 2,4-disubstituted azetidines.

Abstract

Treatment of N-tosylaldimines with acetophenone at room temperature in the presence of BF(3).OEt(2) as a catalyst furnished the corresponding N-tosyl beta-amino ketones in high yields (77-86%) within 6-9 h. Subsequent reduction and cyclization of these compounds afforded 2,4-disubstituted N-tosylazetidines, comprising a three-step, high-yielding synthesis… (More)
DOI: 10.1021/jo901982n

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Cite this paper

@article{Das2009SimpleAE, title={Simple and efficient access to N-tosyl beta-amino ketones and their conversion into 2,4-disubstituted azetidines.}, author={Biswanath Das and Penagaluri Balasubramanyam and Boyapati Veeranjaneyulu and Gandolla Chinna Reddy}, journal={The Journal of organic chemistry}, year={2009}, volume={74 24}, pages={9505-8} }