• DOI:10.1055/S-0033-1339639
• Corpus ID: 98320292

Simple Procedures for the Preparation of 1,3,5-Substituted 2,4,6-Trimethoxybenzenes

@article{Nielsen2013SimplePF,
  title={Simple Procedures for the Preparation of 1,3,5-Substituted 2,4,6-Trimethoxybenzenes},
  author={Bjarne E Nielsen and Henrik Gotfredsen and Brian Schou Rasmussen and Christian Gregers Tortzen and Michael Pittelkow},
  journal={Synlett},
  year={2013},
  volume={24},
  pages={2437-2442}
}

• Bjarne E Nielsen, Henrik Gotfredsen, +2 authors M. Pittelkow
• Published 27 August 2013
• Chemistry
• Synlett

We describe straightforward protocols for the preparation of a number of 1,3,5-substituted 2,4,6-trimethoxybenzenes. A two-step procedure for the preparation of a 1,3,5- tris -methylamino-2,4,6-trimethoxybenzene and further synthetic elaboration of this key substrate to yield a triamide, a tricarbamate and three different triureas is described. We also present a computational (DFT) study that investigates the different possible conformations of the overcrowded benzene substrate and a single-crystal X-ray structure of one of the key intermediates.