Simple “On‐Demand” Production of Bioactive Natural Products

@article{Bode2015SimpleP,
  title={Simple “On‐Demand” Production of Bioactive Natural Products},
  author={Edna Bode and Alexander O. Brachmann and C. Kegler and Rukayye Simsek and Christina Dauth and Qiuqin Zhou and M. Kaiser and Petra Klemmt and H. Bode},
  journal={ChemBioChem},
  year={2015},
  volume={16}
}
  • Edna Bode, Alexander O. Brachmann, +6 authors H. Bode
  • Published 2015
  • Chemistry, Medicine
  • ChemBioChem
  • Exchange of the native promoter to the arabinose‐inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the “on‐demand” production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel “mevalagmapeptides” and the highly toxic xenorhabdins were identified by this approach. 

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