Simple "on-demand" production of bioactive natural products.

  title={Simple "on-demand" production of bioactive natural products.},
  author={Edna Bode and Alexander O. Brachmann and C. Kegler and Rukayye Simsek and Christina Dauth and Qiuqin Zhou and M Kaiser and Petra A.B. Klemmt and Helge B Bode},
  journal={Chembiochem : a European journal of chemical biology},
  volume={16 7},
Exchange of the native promoter to the arabinose-inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the "on-demand" production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel "mevalagmapeptides" and the highly toxic xenorhabdins were identified by this approach. 
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Published online on

  • F. Grundmann, M. Kaiser, +6 authors J. Nat
  • Wiley-VCH Verlag GmbH & Co. KGaA,
  • 2015
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  • J. B. Biggins, X. Liu, Z. Feng, S. F. Brady, J. Am
  • Soc. 2011, 133, 1638 –
  • 1641

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