Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

  title={Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon},
  author={Seymore Herling and Edward H. Coale and David W. Hein and Gail D. Winger and James H. Woods},
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds… 

Phencyclidine-like discriminative stimulus properties of opioids in the squirrel monkey

The PCP-like stimulus effects of certain opioids appear to be mediated at neuronal substrates acted upon by PCP rather than at sites typically associated with opiate activity, which may correspond to the sigma “opiate” receptor.

Generalization of the discriminative stimulus properties of phencyclidine to other drugs in the pigeon using color tracking under second order schedules

Pigeons were trained to track the location of a red or green key color under a second order schedule, with reinforcement of responses to each color contingent upon whether 1.5 mg/kg phencyclidine

Discriminative stimulus properties of narcotic and non-narcotic drugs in rats trained to discriminate opiate ϰ-receptor agonists

The usefulness of the discriminative stimulus properties of some narcotic and nonnarcotic drugs in rats trained to discriminate the effect of the proposed opiate ϰ-receptor agonists ethylketocyclazocines and bremazocine is suggested.

Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action

The time-course of the discriminative stimulus effects of barbiturates in the rhesus monkey appears to parallel closely other pharmacological actions of these compounds.

The ketamine analogue methoxetamine generalizes to ketamine discriminative stimulus in rats

The present findings suggest that investigation of ‘ketamine-like compounds’ should explore not only substances with chemical analogy and common molecular mechanisms with ketamine, but also with similar psychopharmacological effects.

Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP

The notion that PCP, metaphit, and AP5 have a common discriminative effect in pigeons is supported.

Ketamine and phencyclidine: the good, the bad and the unexpected

The discovery in 1983 of the NMDA receptor antagonist property of ketamine and phencyclidine was a key step to understanding their pharmacology, including their psychotomimetic effects in man, and its expansion into other hallucinatory drugs.

Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine

It is suggested that the NR2B subunit is involved in the discriminative stimulus effects of noncompetitive NMDA antagonists, and that selective NR2 B antagonists may also induce psychotomimetic side-effects.

Self-administration of Δ9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys

THC can act as an effective reinforcer of drug-taking behavior in monkeys with no history of exposure to other drugs, suggesting that self-administration of THC by monkeys provides a reliable animal model of human marijuana abuse.

Self-administration of cannabinoids by experimental animals and human marijuana smokers



A comparison of the discriminable CNS effects of ketamine, phencyclidine and pentobarbital.

  • D. Overton
  • Psychology, Biology
    Archives internationales de pharmacodynamie et de therapie
  • 1975
In a shock-escape T-maze task, rats were required to learn drug discriminations involving various doses of pentobarbital, phencyclidine and ketamine, and drug vs drug training demonstrated that phencyclamines differed discriminably from each other.

Phencyclidine-like discriminative effects of opioids in the rat.

  • S. Holtzman
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1980
Results provide further evidence that PCP and certain opioids share a common component of action that is probably mediated by neuronal substrates not usually associated with the activity of opioids.

Discriminative stimulus properties of phencyclidine

Antagonism of the effects of pentobarbital in the chronic spinal dog by naltrexone.

Investigation of narcotics and antitussives using drug discrimination techniques.

Number of training sessions before criterion performance (STC) was used to indicate degree of discriminability of the training drug, and decreased monotonically as dosage increased, and reached a minimum of 3 to 26 with various agonists.

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

  • P. GilbertW. Martin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1976
Data from the study of morphine-like and nalorphine-like drugs studied in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog are consistent with the hypothesis that there are strong and partial agonists of the mu and kappa types, and further, that physical dependence on morphine and cyclzocine is mediated through different receptors.

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists.

Discriminative properties of narcotic antagonists.

Since the abuse potential of narcotic analgesics is largely a function of the nature of their subjective effects, animal models for evaluating this component of drug action are of obvious importance on clinical as well as on theoretical grounds.

Evaluation of the discriminative effects of morphine in the rat.

Morphine-like discriminative effects were produced uniquely by the narcotic analgesics and euophorogenic analgesics with mixed agonist and narcotic antagonist properties.