Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

@article{Herling2004SimilarityOT,
  title={Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon},
  author={Seymore Herling and Edward H. Coale and David W. Hein and Gail D. Winger and James H. Woods},
  journal={Psychopharmacology},
  year={2004},
  volume={73},
  pages={286-291}
}
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds… 

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References

SHOWING 1-10 OF 34 REFERENCES

A comparison of the discriminable CNS effects of ketamine, phencyclidine and pentobarbital.

  • D. Overton
  • Psychology, Biology
    Archives internationales de pharmacodynamie et de therapie
  • 1975
In a shock-escape T-maze task, rats were required to learn drug discriminations involving various doses of pentobarbital, phencyclidine and ketamine, and drug vs drug training demonstrated that phencyclamines differed discriminably from each other.

Phencyclidine-like discriminative effects of opioids in the rat.

  • S. Holtzman
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1980
Results provide further evidence that PCP and certain opioids share a common component of action that is probably mediated by neuronal substrates not usually associated with the activity of opioids.

Discriminative stimulus properties of phencyclidine

Antagonism of the effects of pentobarbital in the chronic spinal dog by naltrexone.

Investigation of narcotics and antitussives using drug discrimination techniques.

Number of training sessions before criterion performance (STC) was used to indicate degree of discriminability of the training drug, and decreased monotonically as dosage increased, and reached a minimum of 3 to 26 with various agonists.

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

  • P. GilbertW. Martin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1976
Data from the study of morphine-like and nalorphine-like drugs studied in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog are consistent with the hypothesis that there are strong and partial agonists of the mu and kappa types, and further, that physical dependence on morphine and cyclzocine is mediated through different receptors.

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists.

Discriminative properties of narcotic antagonists.

Since the abuse potential of narcotic analgesics is largely a function of the nature of their subjective effects, animal models for evaluating this component of drug action are of obvious importance on clinical as well as on theoretical grounds.

Evaluation of the discriminative effects of morphine in the rat.

Morphine-like discriminative effects were produced uniquely by the narcotic analgesics and euophorogenic analgesics with mixed agonist and narcotic antagonist properties.