Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging

@article{Wang2004SimilarityBO,
  title={Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging},
  author={G. Wang and N. Volkow and P. Thanos and J. Fowler},
  journal={Journal of Addictive Diseases},
  year={2004},
  volume={23},
  pages={39 - 53}
}
  • G. Wang, N. Volkow, +1 author J. Fowler
  • Published 2004
  • Medicine
  • Journal of Addictive Diseases
  • SUMMARY Overeating in obese individuals shares similarities with the loss of control and compulsive drug taking behavior observed in drug-addicted subjects. The mechanism of these behaviors is not well understood. Our prior studies with positron emission tomography (PET) in drug-addicted subjects documented reductions in striatal dopamine (DA) D2 receptors. In pathologically obese subjects, we found reductions in striatal DA D2 receptors similar to that in drug-addicted subjects. Moreover, DA… CONTINUE READING
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    References

    SHOWING 1-10 OF 73 REFERENCES
    Brain dopamine and obesity
    • 1,487
    • PDF
    Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
    • 389
    • PDF
    Decreases in dopamine receptors but not in dopamine transporters in alcoholics.
    • 500
    Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.
    • 399
    • PDF
    Relationships between Mesolimbic Dopamine Function and Eating Behavior a
    • 83