Similarity Among the Drosophila (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family

@article{Todo1996SimilarityAT,
  title={Similarity Among the Drosophila (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family},
  author={Takeshi Todo and Haruko Ryo and K. Yamamoto and Hiroyuki Toh and T Inui and Hitoshi Ayaki and Taisei Nomura and Mitsuo Ikenaga},
  journal={Science},
  year={1996},
  volume={272},
  pages={109 - 112}
}
Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts [(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the… Expand
Flavin adenine dinucleotide as a chromophore of the Xenopus (6-4)photolyase.
Two types of enzyme utilizing light from the blue and near-UV spectral range (320-520 nm) are known to have related primary structures: DNA photolyase, which repairs UV-induced DNA damage in aExpand
Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana.
TLDR
This is the first demonstration of a requirement for this gene for photoreactivation of 6-4 products in vivo, and the isolation of a homolog of this gene is reported, cloned from the higher plant Arabidopsis thaliana. Expand
A Putative Blue‐Light Receptor From Drosophila melanogaster
TLDR
R reverse transcription polymerase chain reaction analysis showed that the gene is more expressed in head than in body and that it is more expression in antennae than in legs, wings and mouth appendages, suggesting different roles of the photolyase homologs. Expand
Characterization of Arabidopsis photolyase enzymes and analysis of their role in protection from ultraviolet-B radiation.
TLDR
These studies indicate that Arabidopsis possesses the photorepair capacity to respond effectively to increased UV-B-induced DNA damage under conditions predicted to be representative of increases inUV-B irradiation levels at the Earth's surface and global warming in the twenty-first century. Expand
Non-mutagenic repair of (6-4)photoproducts by (6-4)photolyase purified from Drosophila melanogaster.
TLDR
Photoreactivation of (6-4)photoproduct constructed in M13 phage eliminates the replication block and abolishes induced mutagenesis in E. coli cells, suggesting that the (6,4)photolyase repairs the photoproductor to the unmodified form. Expand
A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification
TLDR
A gene that encodes a protein with class II CPD photolyase activity in vitro has been cloned from several plants including Arabidopsis thaliana, Cucumis sativus and Chlamydomonas reinhardtii, which was cloned on the basis of sequence similarity and PCR-based dilution-amplification. Expand
A gene required for the novel activation of a class II DNA photolyase in Chlamydomonas.
TLDR
PHR2 is the structural gene for the photolyase targeted to both the chloroplast and the nucleus, and that the PHR1 gene product is necessary for full activity of PHR2 protein. Expand
Characterization of a human homolog of (6-4) photolyase.
TLDR
A human cDNA clone which has high sequence homology to the (6-4)photolyase gene (H 64PRH gene) was identified and a genomic clone corresponding to the H64PRH cDNA was isolated and mapped it to chromosome 12q24.1 by fluorescence in situ hybridization (FISH). Expand
(6-4) photolyase: light-dependent repair of DNA damage.
  • X. Zhao, D. Mu
  • Biology, Medicine
  • Histology and histopathology
  • 1998
TLDR
This review focuses on the discussion of the photolyase specific for repairing p Skyrimidine-(6-4)-pyrimidone photoproducts mainly because the research of the cyclobutane pyrimidine dimer photolyases has recently been reviewed quite extensively. Expand
Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803.
TLDR
Phylogenetic analysis showed that sll1629 is more closely related to the cryptochromes than photolyases, and this is the first description of a bacterial cryptochrome. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Characterization of (6-4) photoproduct DNA photolyase.
TLDR
It is shown that the (6-4) photoproduct but not its Dewar isomer is the substrate for the enzyme, that the enzyme has an action spectrum peak at 400 nm, and that the efficiency of repair per incident photon is very low compared with cyclobutane pyrimidine dimer photolyases. Expand
A new class of DNA photolyases present in various organisms including aplacental mammals.
TLDR
The results suggest a divergence of photolyase genes in early evolution and a new classification for photolyases comprising two distantly related groups is proposed. Expand
Cloning of a marsupial DNA photolyase gene and the lack of related nucleotide sequences in placental mammals.
TLDR
The results strongly suggest that humans, as well as other placental mammals, lack the photolyase gene. Expand
High-level expression of the photorepair gene in Drosophila ovary and its evolutionary implications.
TLDR
The phr gene of Drosophila has about 60% identical amino acid sites with that of goldfish but only 13-18% with those of microorganisms, overviewing the diversified characteristics of phr genes in various organisms that have presumably evolved from a common ancestral gene. Expand
A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts
TLDR
It is reported here that an enzyme that catalyses the light-dependent repair of (6–4)photoproduct exists in Drosophila melanogaster, the first report of such photoreactivating activity specific for (6-4) photographers in any organism. Expand
Putative blue-light photoreceptors from Arabidopsis thaliana and Sinapis alba with a high degree of sequence homology to DNA photolyase contain the two photolyase cofactors but lack DNA repair activity.
TLDR
The putative blue-light photoreceptor genes of Arabidopsis thaliana and Sinapis alba (mustard) are highly homologous to the DNA repair genes encoding DNA photolyases, and their chromophore composition suggests that the blue light photoreceptors may initiate signal transduction by a novel pathway which involves electron transfer. Expand
Structure and function of DNA photolyase.
TLDR
DNA photolyase repairs DNA by utilizing the energy of visible light to break the cyclobutane ring of the dimer and restores the dipyrimidine and the functional form of flavin ready for a new cycle of catalysis. Expand
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
TLDR
The data reviewed in this article support the notion that the (6-4) photoproduct and its Dewar photoisomer are important cytotoxic determinants of UV light. Expand
UV MUTAGENIC PHOTOPRODUCTS IN Escherichia coli AND HUMAN CELLS: A MOLECULAR GENETICS PERSPECTIVE ON HUMAN SKIN CANCER *
  • D. Brash
  • Chemistry, Medicine
  • Photochemistry and photobiology
  • 1988
TLDR
The local structure of DNA is more important in determining the frequency of mutation at a site than is the photoproduct frequency at that site, and the effect of DNA structure appears to be due to site‐specific lethality. Expand
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
TLDR
The hy4 mutant5 is one of several mutants that are selectively insensitive to blue light during the blue-light-dependent inhibition of hypocotyl elongation response, which suggests that they lack an essential component of the cryptochrome-associated light-sensing pathway. Expand
...
1
2
3
...