Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.

@article{Arajo2015SimilaritiesAD,
  title={Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.},
  author={Fabiano C. Ara{\'u}jo and Amy Milsted and Ingrid Kazue Mizuno Watanabe and Helen Lima Del Puerto and Robson Santos and Jozef Lazar and F M Reis and Jeremy W. Prokop},
  journal={Physiological genomics},
  year={2015},
  volume={47 5},
  pages={177-86}
}
The renin-angiotensin system (RAS) is subject to sex-specific modulation by hormones and gene products. However, sex differences in the balance between the vasoconstrictor/proliferative ACE/ANG II/AT1 axis, and the vasodilator/antiproliferative ACE2/ANG-(1-7)/MAS axis are poorly known. Data in the rat have suggested the male-specific Y-chromosome gene Sry… CONTINUE READING