Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes.

Abstract

In addition to primary human hepatocytes, hepatoma cell lines, and transfected nonhepatoma, hepatic cell lines have been used for pharmacological and toxicological studies. However, a systematic evaluation and a general report of the gene expression spectra of drug-metabolizing enzymes and transporters (DMETs) in these in vitro systems are not currently… (More)
DOI: 10.1124/dmd.110.035873

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@article{Guo2011SimilaritiesAD, title={Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes.}, author={Lei Guo and Stacey L. Dial and Leming Shi and William S. Branham and Jie Liu and J L Fang and Bridgett L Green and Helen Deng and Jim Kaput and Baitang Ning}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2011}, volume={39 3}, pages={528-38} }