Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin.

@article{Nagy1999SimilaritiesAD,
  title={Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin.},
  author={Istv{\'a}n Nagy and Humphrey P Rang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 24},
  pages={10647-55}
}
We have compared the membrane response of rat primary sensory neurons to capsaicin and noxious heat, using electrophysiological and ion flux measurements. Our aim was to determine whether, as recently proposed, the same molecular entity accounts for excitation by both types of stimulus. The properties of the ion channels activated by heat and capsaicin show many similarities but also important differences. The calcium permeability of heat-activated channels is lower than that of capsaicin… CONTINUE READING