Similarities and differences between selective and nonselective BAFF blockade in murine SLE.

@article{Ramanujam2006SimilaritiesAD,
  title={Similarities and differences between selective and nonselective BAFF blockade in murine SLE.},
  author={Meera Ramanujam and Xiaobo Wang and Weiqing Huang and Zheng Liu and Lena Schiffer and Haiou Tao and Daniel Frank and Jeffrey Rice and Betty Diamond and Karl O. A. Yu and Steven A. Porcelli and Anne Davidson},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 3},
  pages={724-34}
}
B cells have multiple roles in immune activation and inflammation separate from their capacity to produce antibodies. B cell depletion is currently under intense investigation as a therapeutic strategy for autoimmune diseases. The TNF family members B cell-activating factor of the TNF family (BAFF) and its homolog A proliferation-inducing ligand (APRIL) are B cell survival and differentiation factors and are therefore rational therapeutic targets. We compared the effects of BAFF receptor-Ig… CONTINUE READING

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B cell depletion is currently under intense investigation as a therapeutic strategy for autoimmune diseases .
B cell depletion is currently under intense investigation as a therapeutic strategy for autoimmune diseases .
B-LymphocytesIs normal cell origin of diseaseChronic Lymphocytic Leukemia
The TNF family members B cell - activating factor of the TNF family ( BAFF ) and its homolog A proliferation - inducing ligand ( APRIL ) are B cell survival and differentiation factors and are therefore rational therapeutic targets .
TNFSF13B geneGene encodes gene productTNFSF13B protein, human
We compared the effects of BAFF receptor - Ig , which blocks only BAFF , with those of transmembrane activator and calcium modulator ligand interactor - Ig , which blocks both BAFF and APRIL , in a murine SLE model .
We compared the effects of BAFF receptor - Ig , which blocks only BAFF , with those of transmembrane activator and calcium modulator ligand interactor - Ig , which blocks both BAFF and APRIL , in a murine SLE model .
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