Similar rates of production of T and B lymphocytes in the bone marrow

  title={Similar rates of production of T and B lymphocytes in the bone marrow},
  author={Sussan Dejbakhsh-Jones and Hajime Okazaki and Samuel Strober},
  journal={The Journal of Experimental Medicine},
  pages={2201 - 2211}
The rate of renewal of T lymphocytes in the bone marrow of euthymic C57BL/Ka and athymic nu/nu BALB/c mice was estimated by in vivo labeling with bromodeoxyuridine. T lymphocytes accounted for 16-18% of marrow cells in euthymic mice as judged by immunofluorescent staining with monoclonal antibodies for Thy-1, CD3, and alpha/beta T cell antigen receptor markers. About 70% of marrow cells expressed receptors (Mac-1, Gr-1, B220) for myeloid, macrophage, and B lineage cells. Approximately 13% of… CONTINUE READING


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