Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves

@article{Vijverberg1982SimilarMO,
  title={Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves},
  author={H. Vijverberg and J. V. D. Zalm and J. V. D. Bercken},
  journal={Nature},
  year={1982},
  volume={295},
  pages={601-603}
}
Synthetic pyrethroids are a new class of highly active insecticides with great potential for practical application1. They are generally recognized as neurotoxicants that act directly on excitable membranes2,3. Previous studies have shown that the effect of the pyrethroid allethrin closely resembles that of the classical insecticide dichlorodiphenyl trichloroethane (DDT) in the peripheral nervous system of Xenopus laevis4,5. Both compounds induce intense repetitive activity in sense organs and… Expand
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