Similar genotypes of Pneumocystis jirovecii in different forms of Pneumocystis infection.

@article{Totet2004SimilarGO,
  title={Similar genotypes of Pneumocystis jirovecii in different forms of Pneumocystis infection.},
  author={Anne Totet and Hyacinthe Duwat and Eline Magois and Vincent Jounieaux and Patricia Roux and Christian P. Raccurt and Gilles Nevez},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 5},
  pages={
          1173-8
        }
}
This study describes the genotyping of Pneumocystis jirovecii organisms isolated from three groups of patients that developed diverse forms of P. jirovecii infection; the patients were monitored in the same French hospital. Forty archival specimens from 13 adults with Pneumocystis pneumonia, eight adults colonized by P. jirovecii and 19 immunocompetent infants infected with the fungus contemporaneously with a bronchiolitis episode were analysed retrospectively. Genotyping was performed by… 
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Pneumocystis jirovecii multilocus gene sequencing: findings and implications.
TLDR
The CYB, DHFR, DHPS, mtLSU rRNA, SOD and the ITS loci are suitable genetic targets to be used in further epidemiological studies focused on the identification and characterization of P. jirovecii haplotypes correlated with drug resistance and PcP outcome.
Genetic diversity of Pneumocystis jirovecii in colonized Cuban infants and toddlers.
11 Molecular Epidemiology of Pneumocystis Outbreaks
TLDR
Underlying pulmonary disease, transplanted organ dysfunction, and lower CD4 lymphocyte counts were identified as new clinical risk factors for PCP, and two non-mutually exclusive hypotheses can explain the selection of the Pneumocystis genotypes that were responsible for the outbreaks.
Genotyping of Pneumocystis jiroveci Pneumonia in Italian AIDS Patients: Clinical Outcome Is Influenced by Dihydropteroate Synthase and Not by Internal Transcribed Spacer Genotype
TLDR
The present data suggest the absence of a correlation between P. jiroveci ITS types and specific clinical characteristics, and a trend of association is shown between DHPS mutations and some clinical PcP features.
Molecular epidemiology of Pneumocystis jiroveci in human immunodeficiency virus-positive and -negative immunocompromised patients in The Netherlands.
TLDR
The distribution of P. jiroveci genotypes in immunocompetent and Immunocompromised patients in The Netherlands is determined and the clinical relevance of these detected mutations is determined.
Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii
TLDR
The most common methods to identify dihydropteroate synthase (DHPS) mutations, their geographical distribution around the world, and their clinical implications are analyzed, and new emerging DHPS mutations are described.
Drug Resistance in Pneumocystis jirovecii
TLDR
It is clear that mutations involved in sulfa and atovaquone drug resistance have emerged in P. jirovecii as a result of selective pressure by the widespread use of PCP prophylaxis, and it is possible that high-level sulfa resistance could emerge and lead to the loss of the most efficient and inexpensive therapy for PCP.
Revisión El ser humano como reservorio de Pneumocystis
TLDR
The growing interest in P. jirovecii colonization may prompt the design of new prevention and management strategies for PCP, which seems to act as a human reservoir for the fungus.
Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans
TLDR
It is demonstrated that PjRtt109 is a functional Rtt109 HAT, and they support the development of anti-Pneumocystis agents directed at Rtt 109-catalyzed histone acetylation as a novel therapeutic target for human PcP.
El ser humano como reservorio de Pneumocystis
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