Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets.

@article{Jensen2013SimilarEO,
  title={Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets.},
  author={Michael Ladegaard Jensen and Per Torp Sangild and Mikkel Lykke and Mette Schmidt and Mette Boy{\'e} and Bent Borg Jensen and Thomas Thymann},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2013},
  volume={305 1},
  pages={
          R4-R12
        }
}
Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts similar effects and that this effect is partly species-independent. Preterm piglets (n = 40) received… 

Tables from this paper

Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs.

TLDR
Early feeding with formula induces intestinal dysfunction whereas bovine colostrum supports gut maturation when mother's milk is absent during the first week after preterm birth, and a diet-dependent feeding guideline may be required for newborn preterm infants.

Bovine colostrum improves neonatal growth, digestive function, and gut immunity relative to donor human milk and infant formula in preterm pigs.

TLDR
BC, and to some degree DM, are superior to preterm IF in stimulating gut maturation and body growth, using a gradual advancement of enteral feeding volume over the first 11 days after preterm birth in piglets.

Bovine Colostrum Before or After Formula Feeding Improves Systemic Immune Protection and Gut Function in Newborn Preterm Pigs

TLDR
Colostrum feeding ameliorated detrimental effects of formula feeding on systemic immunity and gut health in preterm newborns, especially when given immediately after birth.

Human Milk Fortification with Bovine Colostrum Is Superior to Formula‐Based Fortifiers to Prevent Gut Dysfunction, Necrotizing Enterocolitis, and Systemic Infection in Preterm Pigs

TLDR
Used as a fortifier to DHM, BC is superior to FFs to support gut function, nutrient absorption, and bacterial defense mechanisms in preterm pigs.

Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs.

TLDR
It is concluded that enteral, but not parenteral, administration of antibiotics reduces gut bacterial colonization, inflammation, and NEC lesions in newborn, formula-fed preterm pigs.

Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health

TLDR
Human trials and animal studies are reviewed to assess the scientific evidence of whether BC is a safe and effective antimicrobial and immunomodulatory nutritional supplement that reduces clinical complications related to preterm birth, infections, and gut disorders.

Spray Dried, Pasteurised Bovine Colostrum Protects Against Gut Dysfunction and Inflammation in Preterm Pigs

TLDR
Spray drying and pasteurisation affect BC proteins, but do not reduce the trophic and anti-inflammatory effects of BC on the immature intestine, and it remains to be studied if BC products will benefit preterm infants just after birth when human milk is often not available.

Human milk oligosaccharide effects on intestinal function and inflammation after preterm birth in pigs.

Bovine Colostrum for Preterm Infants in the First Days of Life: A Randomized Controlled Pilot Trial

TLDR
The results indicate that it is feasible to use BC as a supplement to MM during the first weeks of life to increase enteral protein intake in preterm infants, and plasma tyrosine levels may be a good marker for excessive protein intake.

Provision of Amniotic Fluid During Parenteral Nutrition Increases Weight Gain With Limited Effects on Gut Structure, Function, Immunity, and Microbiology in Newborn Preterm Pigs.

TLDR
Enteral provision of AF before the initiation of milk feeding may stimulate body growth and improve hydration in preterm infants receiving PN, and it may improve GI motility and integrity, although most markers of GI maturation remain unchanged.
...

References

SHOWING 1-10 OF 48 REFERENCES

Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs

TLDR
In conclusion, OPN had only moderate NEC-protective effects, while formulas enriched with Gang or SL were ineffective, and the observed modulation of DC cytokine response by bovine colostrum whey in vitro may be due to a synergistic action of various milk bioactives.

Enteral feeding induces diet-dependent mucosal dysfunction, bacterial proliferation, and necrotizing enterocolitis in preterm pigs on parenteral nutrition.

TLDR
Enteral feeding is associated with gut dysfunction, microbial imbalance, and NEC in preterm pigs, especially in pigs fed formula after TPN, and colostrum milk diets improve gut maturation and NEC resistance in pre term pigs subjected to a few days of TPN after birth.

Diet-dependent effects of minimal enteral nutrition on intestinal function and necrotizing enterocolitis in preterm pigs.

TLDR
Colostrum MEN improves intestinal structure, function, and NEC resistance in preterm pigs but does not protect against gut dysfunction and NEC associated with later full enteral formula feeding.

Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review

TLDR
Meta-analysis found that feeding with donor human milk was associated with a significantly reduced relative risk of NEC, and it may be appropriate to consider further larger trials to compare growth, development, and the incidence of adverse outcomes in preterm infants who receive donor human Milk versus formula milk.

Total parenteral nutrition adversely affects gut barrier function in neonatal piglets.

TLDR
TPN is associated with impairment of neonatal gut barrier function as measured by permeability but not translocation, and only claudin-1 protein abundance was increased in the TPN group.

Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs.

TLDR
It is concluded that carbohydrate maldigestion is sufficient to increase the incidence and severity of NEC in preterm pigs.

Bovine colostrums: a review of clinical uses.

  • G. Kelly
  • Biology, Medicine
    Alternative medicine review : a journal of clinical therapeutic
  • 2003
TLDR
Specific hyperimmune bovine colostrums, produced to have high neutralizing titer activity against Cryptosporidia, H. pylori, measles, rotavirus, and Shigella sp.

Formula-feeding reduces lactose digestive capacity in neonatal pigs.

TLDR
It is concluded that formula-feeding may exert detrimental effects on intestinal function in neonates and Formula-induced subclinical malfunction of the gut in pigs born at term was associated with altered NO synthase activity and antioxidative capacity.

Effects of a bovine colostrum-supplemented diet on some gut parameters in weaned piglets.

TLDR
A diet supplemented with colostrum induced, although not always significantly, variations of gut parameters, suggesting that globally, colostrums may limit weaning-induced gut structural and microbial alterations.

Bovine colostrum is a health food supplement which prevents NSAID induced gut damage

TLDR
Bovine colostrum could provide a novel, inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut and may also be of value for the treatment of other ulcerative conditions of the bowel.