Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies.

@article{Lorkeers2015SimilarEO,
  title={Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies.},
  author={Sanne Johanna Jansen of Lorkeers and Joep Egbert Coenraad Eding and Hanna M Vesterinen and Tycho Ids Gijsbert van der Spoel and Emily S Sena and Henricus Johannes Duckers and Pieter Adrianus Doevendans and Malcolm R. Macleod and Steven A. J. Chamuleau},
  journal={Circulation research},
  year={2015},
  volume={116 1},
  pages={80-6}
}
RATIONALE In regenerative therapy for ischemic heart disease, use of both autologous and allogeneic stem cells has been investigated. Autologous cell can be applied without immunosuppression, but availability is restricted, and cells have been exposed to risk factors and aging. Allogeneic cell therapy enables preoperative production of potent cell lines and immediate availability of cell products, allowing off-the-shelf therapy. It is unknown which cell source is preferred with regard to… CONTINUE READING
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