Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease.

@article{Schneider1997SimilarDO,
  title={Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease.},
  author={Christoph Schneider and Daniel Risser and Lieselotte Kirchner and Erwin Kitzmueller and Nigel J. Cairns and Helmut Prast and Nicolas Singewald and Gert Lubec},
  journal={Neuroscience letters},
  year={1997},
  volume={222 3},
  pages={183-6}
}
In order to study whether Alzheimer-like neuropathological changes involve the central histaminergic system we measured the concentration of histamine, its precursor histidine as well as the activity of histidine decarboxylase (HDC) and histamine-N-methyl-transferase (HMT) in frontal cortex of aging Down syndrome (DS) patients, Alzheimer patients and control individuals. The study populations were also investigated for choline acetyltransferase (ChAT) activity, since reduced ChAT activity is an… CONTINUE READING

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