Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families.

@article{Ward2012SimilarBD,
  title={Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families.},
  author={Colin W. Ward and Michael C Lawrence},
  journal={Current opinion in structural biology},
  year={2012},
  volume={22 3},
  pages={360-6}
}
The insulin and epidermal growth factor receptor families are among the most intensively studied proteins in biology. They are closely related members of the receptor tyrosine kinase superfamily and deregulated signaling by members of either receptor family has been implicated in the progression of a variety of cancers. These receptors have thus emerged as validated therapeutic targets for the development of anti-tumour agents. Recent studies have revealed detail of the ligand-binding sites in… CONTINUE READING

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