Similar antagonism of morphine analgesia by MIF-1 and naloxone in Carassius auratus

@article{Ehrensing1982SimilarAO,
  title={Similar antagonism of morphine analgesia by MIF-1 and naloxone in Carassius auratus
},
  author={Rudolph H. Ehrensing and Gary F. Michell and Abba J. Kastin},
  journal={Pharmacology Biochemistry and Behavior},
  year={1982},
  volume={17},
  pages={757-761}
}
Prolyl-leucyl-glycinamide (MIF-1), the C-terminal tripeptide of oxytocin, and naloxone were administered intracranially (IC) to goldfish (Carassius auratus) in doses of 0.001, 0.01, 0.1, 1.0 and 10.0 mg/kg and compared to a diluent control group for their ability to reduce the effects of morphine (30 mg/kg IC) in an assay measuring analgesia to electric shock. Threshold levels of pain were determined by the voltage necessary to produce an agitated swimming response (ASR). Both MIF-1 and… Expand
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Experiments were performed on carp Cyprinus carpio, rainbow trout Oncorhynchus mykiss, cod Gadus morhua and sturgeon Acipenser ruthenus. An originally designed optico-mechanical system was used toExpand
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TLDR
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TLDR
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TLDR
GTP showed optimal facilitation at a concentration of about 2 microM in both the 3H-DADLE and3H-naloxone "antagonist" conditions, and MIF-1 did not affect these GTP responses, indicating further the lack of effect of this peptide on opiate binding. Expand
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TLDR
The results emphasize the differential actions of MIF-1 as an opiate antagonist and demonstrate that the pituitary is not required for their mediation. Expand
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Results indicate that PLG facilitated the development of morphine tolerance and dependence and increased the hypothermia and body weight loss seen after naloxone-induced withdrawal. Expand
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The data indicate that these peptides do not interfere withe the morphine-morphine receptor complex formation but alter a subsequent step in the genesis of some aspects of tolerance and dependence processes. Expand
Low doses of naloxone and MIF-1 peptides increases fluid consumption in rats
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Three studies with albino rats suggest that in some situations low doses of opiate antagonists may facilitate fluid consumption even though high doses are known to suppress the same behavior. Expand
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TLDR
Of the morphine abstinence symptoms the naloxone-induced jumping in morphine pretreated mice could not be modified either by α-MSH coadministration or by MIF pretreament, but the withdrawal body weight loss was found to be diminished by the former and increased by the latter peptide. Expand
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The effects of prolyl-leucyl-glycinamide (PLG) and thyrotropin releasing hormone (TRH) on morphine-induced catalepsy and the therapeutic potential of PLG in Parkinson's disease are investigated. Expand
Mu and delta opiate receptors in rat brain are affected by GTP but not by MIF-1
TLDR
GTP showed optimal facilitation at a concentration of about 2 microM in both the 3H-DADLE and3H-naloxone "antagonist" conditions, and MIF-1 did not affect these GTP responses, indicating further the lack of effect of this peptide on opiate binding. Expand
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The results reported here confirm the analgesic potency of C-Fragment administered intracerebrally in the rat, and show that chronic administration of the peptide leads to the development of tolerance to its analgesic actions. Expand
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TLDR
Dose-response studies revealed MIF and cyclo(Leu-Gly) to be the most potent peptides and to be effective in blocking physical dependence to morphine at a dose as low as 0.05 microgram per mouse, respectively. Expand
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TLDR
The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations. Expand
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