Similar active genes cluster in specialized transcription factories

@article{Xu2008SimilarAG,
  title={Similar active genes cluster in specialized transcription factories},
  author={Meng Xu and Peter R. Cook},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={615 - 623}
}
How transcription affects the way specific genes are arranged within the nucleus remains to be fully understood. We examine here whether transcription occurs in discrete sites (factories) containing the required machinery and whether these sites specialize in transcribing different genes. We cotransfected plasmids encoding a common origin of replication but different transcription units into cells, where they are assembled into minichromosomes that the cellular machinery replicates and… CONTINUE READING

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