Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models.

@article{Embry2018SimilarBA,
  title={Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models.},
  author={Addie E. Embry and Zhenan Liu and Joel M Henderson and Fitzroy J. Byfield and Liping Liu and Joonho Yoon and Zhenzhen Wu and Katrina Cruz and Sara Moradi and C Barton Gillombardo and Rihanna Z Hussain and Richard Doelger and Olaf Stuve and Audrey N Chang and Paul A. Janmey and Leslie A. Bruggeman and R. Tyler Miller},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2018},
  volume={29 5},
  pages={1501-1512}
}
Background FSGS is a pattern of podocyte injury that leads to loss of glomerular function. Podocytes support other podocytes and glomerular capillary structure, oppose hemodynamic forces, form the slit diaphragm, and have mechanical properties that permit these functions. However, the biophysical characteristics of glomeruli and podocytes in disease remain unclear.Methods Using microindentation, atomic force microscopy, immunofluorescence microscopy, quantitative RT-PCR, and a three-dimensional… CONTINUE READING
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